CHARACTERIZATION AND FUNCTIONAL ANALYSIS OF EXTRACELLULAR VESICLES AND MUSCLE-ABUNDANT MIRNAS (MIR-1, MIR-133A, AND MIR-206) IN C2C12 MYOCYTES AND MDX MICE.

Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder.Here, we show that the CD63 antigen, which is located on the surface of extracellular vesicles (EVs), is associated with increased levels of muscle-abundant miRNAs, namely myomiRs miR-1, miR-133a, and miR-206, in the sera of DMD patients and mdx mice.Furthermore, the release

Background: Activated platelets release serotonin during acute myocardial infarction (AMI), aggravating myocardial damage and ischemia/reperfusion (I/R) injury.However, serum serotonin and its potential role as a biomarker for myocardial infarction and I/R injury have not been studied so far.Methods: In this investigator-initiated pilot study, LED

Loess has a unique structure and water sensitivity, and the immersion of loess leads to many tunnel lining problems in shallowly buried tunnels.Based on a LED Half Moon Standing Lamp tunnel in Gansu Province in China, two failure glide planes of a shallowly buried loess tunnel and their immersion modes are summarized.Finite element calculation of t

Diffusion tensor imaging (DTI) techniques have made it possible to investigate white matter plasticity in humans.Changes in DTI measures, principally increases Pepper Shaker in fractional anisotropy (FA), have been observed following training programs as diverse as juggling, meditation, and working memory.Here, we sought to test whether three month